Macular Corneal Dystrophy (Labrador Retriever Type)(MCD)

Malignant Hyperthermia

Myotonia Congenita (Labrador Retriever Type)

Myotubular Myopathy X-Linked (Labrador Retriever Type)

Oculo-Skeletal Dysplasia (Labrador Retriever Type)

Narcolepsy (Labrador Retriever Type)

Progressive Retinal Atrophy, Progressive Rod-Cone Degeneration (PRCD)

Pyruvate Kinase Deficiency (Labrador Retriever Type)(PKU)

Retinal Dysplasia/Oculoskeletal Dysplasia 1 (RD/OSD)

Skeletal Dysplasia 2 (SD2)(Mild Disproportionate Dwarfism)

Stargardt Disease

Ullrich Congenital Muscular Dystrophy Labrador Retriever Type 2 

At-Risk Genetic Testing:​

New DNA tests for genetic diseases are continually being discovered. 

Some of these tests do not determine definitively if a dog has a specific disease, they only determine if a dog has a mildly or moderately increased risk of developing the disease.  These diseases may have other causes so it is important to know that dogs that test clear may still develop the disease while dogs who test mildly or moderately at-risk may never develop the disease.  

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We believe that all Brookhaven Labradors should be tested for these genetic variants/mutations to make informed breeding decisions,

Seymour's test results are as follows:

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Copper Toxicosis (Labrador Retriever Type is the body's inability to excrete excess copper resulting in chronic liver failure.

          - Type A Protective Gene - this gene protects against the genetic predisposition the Type B At-Risk gene. 

                    *Seymour carries one copy of this gene and will pass the protective ability of this gene on to all of his female offspring.

          - Type B - this gene mildly or modertely increases the risk of developing the disease.

                    *Seymour carries one copy of the at-risk gene, his offspring will have a 50% chance of inheriting it.  Seymour does not

                     carry an increased risk of developing this disease as he carries one A gene and one B gene, which negate each other.

*The ATP7B gene has a VERY LOW TO RARE prediction ability of who will or will not get this disease.

The overwhelming majority of dogs that have this disease do NOT carry the ATP7B gene.

This disease is primarily an environmentally caused disease due to amount and type of copper present in a dog's diet.

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Ehlers-Danlos Syndrome (Labrador Retriever Type) is a Tissue Connective Disease, it is estimated that as many as 20 genes may                                                                                                                   carry the mutation for each variant.

          - Variant 1, Classic Symptoms, it is estimated that 1 in 5,000 Labradors are affected.

                    *Seymour does NOT carry the at-risk gene, him & his offspring will not be at an increased risk towards the disease from her DNA.

          -Variant 2, is less severe than variant one but is rare, it is estimated that 1 in 25,000 Labradors are effected.

                    *Seymour does NOT carry the at-risk gene, him & his offspring will not be at an increased risk towards the disease from her DNA.

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Ullrich Congenital Muscular Dystrophy (Labrador Retriever Type 1)

          - (Labrador Retriever Type 1) is a rare muscle disease in Labradors that appears around 3 to 4 months of age.  It is estimated that 1 in         

             100,000 Labradors are affected.  This disease has two variants, the second variant is a recessive trait so it provides a more definitive

             answer (listed under DNA Genetic Testing above).  Variant 1 is an at-risk trait, so a Labrador who carries one or two of the mutations may

             be affected or might not be affected.  It is possible that Labradors who do not carry this variant can still be affected. 

                    *Seymour does NOT carry the at-risk gene, him & his offspring will not be at an increased risk towards the disease from her DNA.

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